Manifestation of oxidative stress during pregnancy in women with chronic diseases of hepatobiliary system against the background of reproductive losses

In the early stages of gestation changes in lipid peroxidation can lead to violations regulatory and protective functions biomembranes pregnant women. The objective: study concentration intermediate final products LPO during first trimester patients with miscarriage against background chronic diseases hepatobiliary system. Materials methods. 118 women (7-10 weeks), aged 22 - 39 y. o. (mean age 29.4 ± 2.7 years) have been examined.64 (54.2%) were diagnosed a risk miscarriage, 17 involuntary within 10-12 days. All non-viral non-alcoholic HBS paathology: hepatic steatosis had 38 (32.2%), 80 (67.8%) steatohepatitis; 97 (82.2%) non-calculous cholecystitis was diagnosed. state assessed by content malonic dialdehyde spectrophotometrically, as well diene conjugates blood indicator erythrocyte peroxide hemolysis examined level resistance. Results. A significant increase an unfavorable premorbid form system history reproductive losses. MDA DC found at premature termination pregnancy. degree PLO processes activation makes these parameters integrative criteria for detection systemic metabolic disorders GBS extragenital pathology. Conclusion. During physiological pregnancy there is accumulation metabolites peroxidation, which associated basic metabolism oxygen consumption from blood.